Marge Simpson is an enemy in all chapters of Eggs for Bart.
Chapter One[]
Marge is the first enemy you put up with and appears on all nights, she moves aimlessly around the Simpson's house, if she spots you, she'll begin chasing you saying that only eggs can sustain her.
Chapter Two[]
In Chapter 2, Marge works the same exact way as in chapter 1 except since the forest is more spacious, she's always running so she's more of a threat. At the end of Chapter 2 her soul is put to rest as Barney takes the eggs.
Chapter 3[]
In chapter 3, Marge's body can be seen along with the rest of the family in level 1, in level 2, a gridified Marge appears as an enemy and works the same as her chapter 1 counterpart as you are in a gridified version of the Simpson's home.